Toll-like Receptor 4 Asp299Gly Gene Polymorphism and Risk of Atherothrombosis
نویسندگان
چکیده
منابع مشابه
Toll-like receptor 4 Asp299Gly gene polymorphism and risk of atherothrombosis.
BACKGROUND AND PURPOSE Recent findings of an association between a functional toll-like receptor 4 (TLR4) D299G gene variant and reduced risk of atherothrombotic disorders have generated great interest. METHODS We evaluated the TLR4 D299G polymorphism among 695 individuals with incident myocardial infarction (MI) or stroke and among 695 age- and smoking-matched individuals who remained free o...
متن کاملRapid Communication Association of the Toll-Like Receptor 4 Gene Asp299Gly Polymorphism With Acute Coronary Events
Objective—Atherosclerosis is a chronic inflammatory disease of the blood vessels. Toll-like receptor 4 (TLR4) is a transmembrane receptor that is involved in mediating inflammatory responses to bacterial endotoxin and other ligands. The aim of this study was to search for an association between a common functional polymorphism of TLR4— Asp299Gly—and acute coronary syndrome. Methods and Results—...
متن کاملAssociation of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events.
OBJECTIVE Atherosclerosis is a chronic inflammatory disease of the blood vessels. Toll-like receptor 4 (TLR4) is a transmembrane receptor that is involved in mediating inflammatory responses to bacterial endotoxin and other ligands. The aim of this study was to search for an association between a common functional polymorphism of TLR4--Asp299Gly--and acute coronary syndrome. METHODS AND RESUL...
متن کاملToll-like receptor 4 gene Asp299Gly polymorphism in ischemic cerebrovascular disease: a meta-analysis.
Epidemiological studies have evaluated the association between Toll-like receptor 4 (TLR4) gene Asp299Gly (rs4986790) polymorphism and the risk of ischemic cerebrovascular disease, but the results are inconsistent. In an effort to clarify earlier inconclusive results, a meta-analysis was performed. We searched the PubMed, Web of Science, Embase, Cochrane database, Clinicaltrials.gov, Current Co...
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Background: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation. Objective: This case/control study is aimed to investigate whether TLR- 4 896A/G variation is related to migraine headaches in an Iranian po...
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ژورنال
عنوان ژورنال: Stroke
سال: 2005
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000149948.31879.f0